The following weight files are for the GIANT and GIANT+23andMe PGS scores created with PRS-CS and PRS-CSx, respectively:

- **Smit_GIANT_BMI_2025_PRSCS.txt.gz**: the GIANT-only score, created with PRS-CS, using the GIANT ‘ALL’ meta-analysis (excluding the UK Biobank and ALSPAC study) and a 1000G LD reference panel created by Sarah Graham. This is a stand-alone score.

- **Smit_G23_BMI_2025_PRSCSx_META.txt.gz**: GIANT+23andMe score generated with PRS-CSx, using as input 5 GIANT+23andMe meta-analyses (AFR, AMR, EAS, EUR, SAS), excluding the UK Biobank, BioMe, and ALSPAC studies, and the developer-provided 1000G LD reference panels. This is a stand-alone score.

- **Smit_G23_BMI_2025_PRSCSx_LC_AFR.txt.gz**, *AMR.txt.gz, *EAS.txt.gz, *EUR.txt.gz, *SAS.txt.gz: GIANT+23andMe score generated with PRS-CSx, using as input 5 GIANT+23andMe meta-analyses (AFR, AMR, EAS, EUR, SAS), excluding the UK Biobank, BioMe, and ALSPAC studies, and the developer-provided 1000G LD reference panels. These population-specific subscores need to be linearly combined to create the final PGS, with the combination weights depending on the target population (e.g., EAS). The combination weights were derived from the UK Biobank (i.e, tuning population) and are listed below. So, if you want to apply this PGS to an EAS target population, calculate the 5 population-specific scores using the weight files, standardise each within your EAS population, and combine using their respective weights from the table below, and finally standardise the PGS again.

### Linear Combination Weights by Target Population

| Tuning/Target | PGS | Weight |
|---------------|-----|--------|
| AMR           | EUR | 5.37   |
| AMR           | AFR | -0.02  |
| AMR           | EAS | 0.97   |
| AMR           | SAS | 0.39   |
| AMR           | AMR | 1.00   |
| AFR           | EUR | 3.67   |
| AFR           | AFR | 1.00   |
| AFR           | EAS | 0.63   |
| AFR           | SAS | 0.49   |
| AFR           | AMR | 1.11   |
| EAS           | EUR | 0.72   |
| EAS           | AFR | 0.33   |
| EAS           | EAS | 1.00   |
| EAS           | SAS | 0.21   |
| EAS           | AMR | 0.35   |
| EUR           | EUR | 1.00   |
| EUR           | AFR | -0.01  |
| EUR           | EAS | 0.14   |
| EUR           | SAS | 0.05   |
| EUR           | AMR | 0.16   |
| SAS           | EUR | 2.11   |
| SAS           | AFR | 0.21   |
| SAS           | EAS | 0.87   |
| SAS           | SAS | 1.00   |
| SAS           | AMR | 0.68   |